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In contrast with mouse thymocytes, mouse ES cells contain greater levels of complete genomic H3K4me3 and have greater H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 46 In agreement with this, international decreases in H3K4me3 ranges occur during retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic modifications in H3K4me3 profiles at specific sets of genes during ES cell differentiation.

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